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Objective@#To investigate the clinical effect of Astragalus injection combined with meropenem in the treatment of severe infection patients and its influence on T lymphocyte subsets and inflammatory factors in peripheral blood.@*Methods@#From January 2016 to December 2018, 80 patients with severe infections in Yiwu Fuyuan Private Hospital were selected and divided into observation group (n=40) and control group (n=40) according to single blind random table method.The observation group was treated with Astragalus injection combined with meropenem, while the control group was treated with meropenem.Both two groups were treated for 10 days.The therapeutic effects, changes of body temperature, heart rate and respiratory rate, changes of T lymphocyte subsets and inflammatory factors in peripheral blood, and negative time of bacterial culture before and after treatment were compared between the two groups.@*Results@#The total effective rate of the observation group (92.50%) was higher than that of the control group (70.00%) (χ2=6.646, P<0.05). After treatment, the levels of CD3+ [(62.38±4.51)%], CD4+ [(40.63±2.15)%] and CD4+ /CD8+ (1.63±0.18) in the observation group were higher than those in the control group [(57.27±3.19)%, (35.47±1.93)% and (1.30±0.21)] (t=5.850, 11.296, 7.546, all P<0.05). After treatment, the levels of CRP [(28.79±8.74)mg/L], PCT [(0.56±0.12)g/L] and TNF-α [(157.93±20.47)pg/mL] in the observation group were lower than those in the control group [(43.71±12.67)mg/L, (1.10±0.23)g/L and (247.16±34.64)pg/mL] (t=13.640, 13.165, 14.026, all P<0.05). The negative turning time of bacterial culture in the observation group [(4.36±1.29)d] was shorter than that in the control group [(7.43±1.57)d] (t=9.493, P<0.05).@*Conclusion@#Astragalus membranaceus injection combined with meropenem has significant clinical effect in the treatment of patients with severe infections.It can improve cellular immune function and reduce inflammatory reaction, which is worthy of clinical reference.
ABSTRACT
Objective To investigate the clinical effect of Astragalus injection combined with meropenem in the treatment of severe infection patients and its influence on T lymphocyte subsets and inflammatory factors in peripheral blood.Methods From January 2016 to December 2018,80 patients with severe infections in Yiwu Fuyuan Private Hospital were selected and divided into observation group (n＝40) and control group (n＝40) according to single blind random table method.The observation group was treated with Astragalus injection combined with meropen-em,while the control group was treated with meropenem.Both two groups were treated for 10 days.The therapeutic effects,changes of body temperature ,heart rate and respiratory rate ,changes of T lymphocyte subsets and inflammatory factors in peripheral blood ,and negative time of bacterial culture before and after treatment were compared between the two groups.Results The total effective rate of the observation group (92.50%) was higher than that of the control group (70.00%) (χ2 ＝6.646,P＜0.05).After treatment,the levels of CD +3 [(62.38 ±4.51)%],CD+4 [(40.63 ±2.15)%] and CD +4 ／CD+8 (1.63 ±0.18) in the observation group were higher than those in the control group [(57.27 ±3.19)%,(35.47 ±1.93)% and (1.30 ±0.21)] ( t＝5.850,11.296,7.546,all P＜0.05). After treatment,the levels of CRP [(28.79 ±8.74)mg／L],PCT [(0.56 ±0.12) g／L] and TNF-α[(157.93 ± 20.47) pg／mL] in the observation group were lower than those in the control group [(43.71 ±12.67) mg／L, (1.10 ±0.23) g／L and (247.16 ±34.64) pg／mL] ( t ＝13.640,13.165,14.026,all P ＜0.05).The negative turning time of bacterial culture in the observation group [(4.36 ±1.29)d] was shorter than that in the control group [(7.43 ±1.57) d] ( t＝9.493,P＜0.05).Conclusion Astragalus membranaceus injection combined with mero-penem has significant clinical effect in the treatment of patients with severe infections .It can improve cellular immune function and reduce inflammatory reaction ,which is worthy of clinical reference.
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The paper analyzes the application advantages of information technology in medical informatics education.Takes Shanghai Sipo Polytechnic College as an example, it elaborates the specific application of information technology in medical informatics education, including immersion education based on 3D virtual reality technology, two-way video teaching and other aspects.It also gives solutions on current existing problems.
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Objective To investigate the correlation between prognosis of patients with severe acute pancreatitis and changes of plasma albumin. Methods A total of 235 patients with severe pancreatitis who were admitted into hospital from September 2008 to October 2013 were selected as research object. According to the prognosis, they were divided into the survival group (143 cases who were recovered and still alive) and the death group (92 cases who died of the deterioration of diseases). Retrospectively analyzed the basic situation of the pa-tients and the changes of serum albumin levels in the two groups. And the correlation between prognosis of patients with severe acute pancrea-titis and changes of plasma albumin were evaluated by the logistic regression analysis. Results Compared with the death group,there were significant differences (P<0. 05) in terms of age,APCHEⅡ score,Ranson score,SOFA score,length of hospital stay,duration of mechani-cal ventilation,continuous renal replacement therapy,average serum albumin level,decrease of serum albumin within 24 hours,and variation of serum albumin. And ROC curves suggested the best cutoff value of decrease of serum albumin within 24 hours to predict death in patients within 24 hours was 4. 24 g/L,and the best cutoff value of variation of serum albumin to predict death was 13. 6%. Logistic regression analy-sis showed that the major risk factors of death in severe acute pancreatitis were decrease of serum albumin within 24 hours,variation of serum albumin within 24 hours,average serum albumin level,and the APCHEⅡscore. Conclusion Changes in plasma albumin can reflect the se-verity of severe acute pancreatitis,and the sharp decrease of serum albumin within 24 hours can be used as a risk factor for death.